• M. Köber, S. Illa-Tuset, L. Ferrer-Tasies, E. Moreno-Calvo, W. Tatkiewicz1, N. Grimaldi, D. Piña, A. Pérez Pérez, V. Lloveras, J. Vidal-Gancedo, D. Bulone, I. Ratera, J. Skov Pedersen, D. Danino, J. Veciana, J. Faraudo, N. Ventosa. Stable nanovesicles formed through the association of intrinsically planar bilayers. Journal of Colloid and Interface Science, 2023, 631, 202-211. DOI:10.1016/j.jcis.2022.10.104
• S. Zhang, V. Lloveras*, S. Lope, P. Calero, S. Wu, A. P. Candiota*, J. Vidal-Gancedo*. Metal-free Radical Dendrimers as MRI Contrast Agents for Glioblastoma Diagnosis: Ex vivo and In vivo Approaches. Biomacromolecules 2022, 23 (7), 2767-2777. DOI: 10.1021/acs.biomac.2c00088
• V. Lloveras,* P. Elías-Rodríguez, L. Bursi, E. Shirdel, A. R. Goñi, A. Calzolari, J. Vidal-Gancedo.* Multifunctional Switch Based on Spin-labelled Gold Nanoparticles. Nano Lett. 2022, 22, 2, 768–774       DOI: 10.1021/acs.nanolett.1c04294
• Ratera, J. Vidal-Gancedo, D. Maspoch, S. T Bromley, N. Crivillers, M. Mas-Torrent. New perspectives for polychlorinated trityl radicals. J Mater Chem C, 2021, 9, 10610-10623. DOI: 10.1039/d1tc02196f
• V. Lloveras,* J. Vidal-Gancedo.* Polyphosphorhydrazone-Based Radical Dendrimers. Molecules,2021, 26, 1230. DOI: 10.3390/molecules26051230
• E. Badetti,* V. Lloveras, E. Amadio, R. Di Lorenzo, M. Olivares-Marin, A. Tesio, S. Zhang, F. Pan, K.  Rissanen, J. Veciana, D.  Tonti,* J. Vidal-Gancedo,* C. Zonta, G. Licini*. Organic Polyradicals as Redox Mediators: Effect of Intramolecular Radical Interactions on Their Efficiency. ACS Appl. Mater. Interfaces, 2020, 12, 45968-45975. DOI: 10.1021/acsami.0c09386.
• S. Zhang, V. Lloveras, D. Pulido, F. Liko, L. F. Pinto, F.Albericio, M. Royo, J. Vidal-Gancedo.* Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI. Pharmaceutics, 2020, 12, 772. DOI: 10.3390/pharmaceutics12080772
• E. Badetti,* V. Lloveras, F.A. Scaramuzzo, K. Wurst, J. Veciana, J. Vidal-Gancedo,* G. Licini, C. Zonta.* Tris-pyridylmethylamine (TPMA) complexes functionalized with persistent nitronyl nitroxide organic radicals. Dalton Trans. 2020, 49, 10011-10016. DOI: 10.1039/D0DT01553A
• J Vidal-Gancedo,* V Lloveras. Can We Predict the Appearance of the Most Virulent COVID-19 Outbreaks in the World? SSRN 2020. DOI: 10.2139/ssrn.3590087
• L.F. Pinto, V. Lloveras, S. Zhang, F. Liko, J. Veciana, J.L. Muñoz-Gómez, J. Vidal-Gancedo.* Fully Water-Soluble Polyphosphorhydrazone-Based Radical Dendrimers Functionalized with Tyr-PROXYL Radicals as Metal-Free MRI T1 Contrast Agents. ACS Applied Bio Materials. 2020, 3, 1, 369-376. DOI: 10.1021/acsabm.9b00855.
• V. Lloveras, F. Liko, J.L. Muñoz-Gómez, J. Veciana, J. Vidal-Gancedo.* Redox-Active PTM Radical Dendrimers as Promising Multifunctional Molecular Switches. Chem. Mater. 2019, 31, 22, 9400-9412. DOI: 10.1021/acs.chemmater.9b03015.
• V. Lloveras, F. Liko, L. F. Pinto, J. L. Muñoz-Gómez, J. Veciana, and J. Vidal-Gancedo.* Tuning Spin-Spin Interactions in Radical Dendrimers. ChemPhysChem. 2018, 19, 1–9. DOI: 10.1002/cphc.201800372.

• L. Pinto, I. Marín-Montesinos, V. Lloveras, J.L. Muñoz-Gómez, M. Pons, J. Veciana, J. Vidal-Gancedo.* NMR signal enhancement > 50000 times in Fast Dissolution Dynamic Nuclear Polarization. Chem. Commun. 2017, 53, 3757-3760. DOI: 10.1039/C7CC00635G.

•  V. Lloveras, E. Badetti, K. Wurst, V. Chechik, J. Veciana, J. Vidal-Gancedo.* Magnetic and Electrochemical Properties of a Diradical TEMPO-substituted Disulfide in Solution, in a Crystal and anchored on Au(111) forming a SAM. Chem. Eur. J. 2016, 22, 1805-1815. DOI: 10.1002/chem.201503306
• V. Lloveras, E. Badetti, J. Veciana and J. Vidal-Gancedo.* Dynamics of Intramolecular Spin Exchange Interaction of a Nitronyl Nitroxide Diradical in Solution and on Surfaces. Nanoscale. 2016, 8, 5049-5058. DOI: 10.1039/C5NR08824K.
• J.L. Muñoz, E. Monteagudo, V. Lloveras, T. Parella, J. Veciana*, J. Vidal-Gancedo.* Optimized Polarization Build-Up Times in Dissolution DNP-NMR Using a Benzyl Amino Derivative of BDPA. RSC Adv. 2016, 6, 27077-27082. DOI: 10.1039/C6RA00635C
• R.A.L. Silva, I.C. Santos, E.B. Lopes, S. Rabaça, J. Vidal-Gancedo, C. Rovira, M. Almeida, D. Belo. DT TTF Salts with [Cu(dcdmp)2]-; the Richness of Different Stoichiometries. Cryst. Growth Des. 2016, 16, 3924-3931. DOI: 10.1021/acs.cgd.6b00484
• E. Badetti,* V. Lloveras, F. Romano, R. Di Lorenzo, J. Veciana, J. Vidal-Gancedo,* C. Zonta, G. Licini.* Discrimination of Octahedral versus Trigonal Bipyramidal Coordination Geometries of Homogeneous TiIV, VV, and MoVI Amino Triphenolate Complexes Through Nitroxyl Radical Units. Eur. J. Ing. Chem. 2016, 31, 4968-4973. DOI: 10.1002/ejic.201600649 Eur. J. Ing. Chem. 2016, 31, 4939. Cover letter y pefil de los autores. DOI: 10.1002/ejic.201601231
• J. Albalad, J. Aríñez-Soriano, J. Vidal-Gancedo, V. Lloveras, I. Imaz, N. Aliaga Alcalde, D. Maspoch. Hetero-bimetallic Paddlewheel Clusters in Coordination Polymers Formed by a Water-Induced Single-Crystal-to-Single-Crystal Transformation. Chem. Commun. 2016, 52, 13397-13400. DOI: 10.1039/C6CC07653J.
• J.L. Muñoz, E. Monteagudo, V. Lloveras, T. Parella, J. Veciana*, J. Vidal-Gancedo.* A Benzyl Alcohol Derivative of BDPA radical for Fast Dissolution Dynamic Nuclear Polarization NMR spectroscopy. Org. Biomol. Chem. 2015, 13, 2689-2693. DOI: 10.1039/C4OB02356K.
• R.A.L. Silva, I.C. Santos, J. Wright, J.T. Coutinho, L.C.J. Pereira, E.B. Lopes, S. Rabaça, J. Vidal-Gancedo, C. Rovira, M. Almeida, D. Belo. Dithiophene-TTF salts; New ladder structures and spin-ladder behavior. Inorg. Chem. 2015, 54, 7000-7006. DOI: 10.1021/acs.inorgchem.5b01013.
• V. Lloveras, E. Badetti, K. Wurst, J. Vidal-Gancedo.* Synthesis, X-Ray Structure, Magnetic Properties, and a Study of Intra/Intermolecular Radical-Radical Interactions of a Triradical TEMPO Compound. Chem. Phys. Chem. 2015, 16, 3302-3307. DOI: 10.1002/cphc.201500462.
• V. Lloveras, E. Badetti, V. Chechick,* J. Vidal-Gancedo.* Magnetic interactions in spin labelled Au Nanoparticles. J. Phys. Chem. C. 2014, 118 (37), 21622-21629. DOI: 10.1021/jp505231w.
• S. R. González, B. Nieto-Ortega, R. C. G. Cano, V. Lloveras, J. Novoa, F. Mota, J. Vidal-Gancedo, C. Rovira, J.Veciana, E. del Corro, M. Taravillo, V. G. Baonza, T. López Navarrete, J. Casado. Diradicals Acting Through Diamagnetic Phenylene Vinylene Bridges. Raman Spectroscopy as a Probe to Characterize Spin Delocalization. J. Chem. Phys. 2014, 140 (16), 164903-1-9. DOI: 10.1063/1.4871895.
• J. L. Muñoz-Gómez, I. Marín-Montesinos, V. Lloveras, M. Pons, J. Vidal-Gancedo,* J. Veciana.* Novel PTM-TEMPO Biradical for Fast Dissolution Dynamic Nuclear Polarization. Org. Lett. 2014, 16, 5402-5405. DOI: 10.1021/ol502644x.
• E. Badetti, V. Lloveras, J. L. Muñoz-Gómez, R. M. Sebastián, A. M. Caminade, J. P. Majoral, J. Veciana, J. Vidal-Gancedo.* Radical Dendrimers: A Family of Five Generations of Phosphorus Dendrimers Functionalized with TEMPO Radicals. Macromolecules. 2014, 47, 7717-7724. DOI:10.1021/ma502062q
• G. Aragay, A. Frontera, V. Lloveras, J. Vidal-Gancedo, P. Ballester. Different Nature of the Interactions between Anions and HAT(CN)6: From Reversible Anion-π Complexes to Irreversible Electron-Transfer Processes (HAT(CN)6 = 1,4,5,8,9,12-Hexaazatriphenylene. J. Am. Chem. Soc. 2013, 135, 2620-2627. DOI:10.1021/ja309960m.
• M. Gonidec, I. Krivokapic, J. Vidal-Gancedo, E.S. Davies, J. Mc Master, S.M. Gorum, J. Veciana. Highly Reduced Double-Decker Single-Molecule Magnets Exhibiting Slow Magnetic Relaxation. Inorg. Chem. 2013, 52(8), 4464-4471. DOI: 10.1021/ic3027418.
• M. Gonidec, I. Krivokapic, J. Vidal-Gancedo, E.S. Davies, J. Mc Master, S.M. Gorum, J. Veciana. Highly Reduced Double-Decker Single-Molecule Magnets Exhibiting Slow Magnetic Relaxation. Inorg. Chem. 2013, 52(20), 12179. DOI: 10.1021/ic402413t.
• J. Guasch, L. Grisanti, M. Souto, V. Lloveras, J. Vidal-Gancedo, I. Ratera, A. Painelli, C. Rovira, J. Veciana. Intra- and intermolecular charge transfer in aggregates of tetrathiafulvalene-triphenylmethyl radical derivatives in solution. J. Am. Chem. Soc. 2013, 135, 6958-6967. DOI: 10.1021/ja400281b.
• I. E. Kareev, E. Laukhina, V. P. Bubnov, V. M. Martynenko, V. Lloveras, J. Vidal-Gancedo, M. Mas-Torrent, J. Veciana, C. Rovira. Harnessing electron transfer from the perchlorotriphenylmethide anion to Y@C82 (C2V) to engineer an endometallofullerene-based salt. Chem. Phys. Chem. 2013, 14, 1670-1675. DOI: 10.1002/cphc.201300107.
• E. Badetti, V. Lloveras, K. Wurst, R. M. Sebastián, A.-M. Caminade, J.-P. Majoral, J. Veciana, J. Vidal-Gancedo.* Synthesis and structural characterization of a dendrimer model compound based on a cyclotriphosphazene core with TEMPO radicals as substituents. Org. Lett. 2013, 15 (14), 3490-3493. DOI: 10.1021/ol401017c.
• J. Calbo, J. Aragó, F. Otón, V. Lloveras, M. Mas-Torrent, J. Vidal-Gancedo, J. Veciana, C. Rovira, E. Ortí. Tetrathiafulvalene-based mixed-valence acceptor-donor-aceptor triads: a joint theoretical and experimental approach. Chem. Eur. J. 2013, 19 (49), 16656-16664. DOI: 10.1002/chem.201302910
• M. Soto, H. Comalrena, U. Balduzzi, G. Guirado, V. Lloveras, J. Vidal-Gancedo, R. M. Sebastián, J. Marquet. Activation of Weak Nucleophiles: Polyfluorocarbamates from Polyfluoroalcohols Via a Fast Radical Reaction. Tetrahedron Lett. 2013, 54, 6310-6313. DOI: 10.1016/j.tetlet.2013.09.037
• J. Guasch, L. Grisanti, V. Lloveras, J. Vidal-Gancedo, M. Souto, D. C. Morales, M.Vilaseca, C. Sissa, A. Painelli, I. Ratera, C. Rovira, J. Veciana. Induced Self-Assembly of a Tetrathiafulvalene-Based Open-Shell Dyad through Intramolecular Electron Transfer. Angew. Chem. Int. Ed. 2012, 51, 11024-11028. DOI: 10.1002/anie.201203448.
• V. Lloveras, J. Vidal-Gancedo, T. M. Figueira-Duarte, J.-F. Nierengarten, J. J. Novoa, F. Mota, N. Ventosa, C. Rovira, J. Veciana. Tunneling versus Hopping in Mixed-Valence Oligo-p-phenylenevinylene Polychlorinated Bis(triphenylmethyl) Radical Anions. J. Am. Chem. Soc. 2011, 133 (15), 5818-5833. DOI: 10.1021/ja1083859.
• A. Abiad Monge, N. Ferrer-Anglada, V. Lloveras, J. Vidal-Gancedo, S. Roth. Electron spin resonance study of single-walled carbon nanotubes. Phys. Status Solidi B 2011, 248 (11), 2564-2567. DOI: 10.1002/pssb.201100110.
• F. Oton, V. Lloveras, M. Mas-Torrent, J. Vidal-Gancedo, J. Veciana, C. Rovira. Coupling Tetracyanoquinodimethane to Tetrathiafulvalene: A Fused TCNQ-TTF-TCNQ Triad. Angew. Chem. Int. Ed. 2011, 50, 10902-10906. DOI: 10.1002/anie.201104841.

Actualyze Health

Spin-Off created in the United States for the commercialization of the patent Nº: US 62/751637, Minimally-invasive continuous clinical monitoring of small molecules with analytical accurancy.

Activa desde octubre de 2019 hasta junio de 2021.

The interaction of the group with the ICMAB Spectroscopy Service and its technical staff (Dr. Vega Lloveras) has always been very close, particularly with the Electronic Paramagnetic Resonance (EPR) laboratory. Dr. José Vidal Gancedo is a specialist in this technique that is fundamental for the development of the research lines that are carried out in his group. In fact Dr. Vidal Gancedo is the Scientific Manager of the ICMAB EPR laboratory, President of the EPR Spanish Group (GERPE) and the Spanish representative in the European Federation of EPR Groups.

Acces to NANBIOSIS – ICTS platform. CIBER-BBN. (http://www.nanbiosis.es/)

• Radical Dendrimers as New Metal-free MRI Contrast Agents for Glioblastoma Diagnosis (Radical-NEED). CIBER-BBN. 09/2023-09/2024. IP: Vega Lloveras
• Grup de Recerca Consolidat: Nanomol-Bio, ICMAB (CSIC). AGAUR. Nº: 2021 SGR 438. 1/2023 -12/2025. IP: Nora Ventosa.

• In vivo Studies of Radical Dendrimers as Contrast Agents for Magnetic Resonance Imaging. SEVERO OCHOA FUNFUTURE. Smart FUNctional materials for a better FUTURE. FRONTIER INTERDISCIPLINARY PROJECTS 2020 CALL (FUNFUTURE-FIP-2020) 31/9/2021 - 1/8/2023. IP: José Vidal Gancedo.

• MOL4BIO. Processing molecules to create hybrid materials hierarchically structured for biomedical applications. DGICT-MINECO. PID2019-105622RB-I00. 1/6/2020 -  31/6/2023. PIs: Nora Ventosa and Imma Ratera.  Work Package WPB2. Radical dendrimers as MRI contrast agents y WPB4 EPR glucose sensor based on radical dendrimers are lidded by José Vidal Gancedo.

• FUNMAT-FIP-2018. Developing New Contrast Agents for Magnetic Resonance Imaging. Smart FUNctional MATerials for Social Grand Challenges. Frontier Interdisciplinary Proyects 2018. SEVERO OCHOA ICMAB project. 1/08/2018 – 31/12/2019. PI: José Vidal Gancedo.
• Red de Dendrímeros para aplicaciones Biomédicas. Ministerio de Economía, Industria y competitividad. CTQ2017-90596-REDT. 1/01/2018 – 31/12/2019. Coordinador: Rafael Gómez Ramirez. PI: José Vidal Gancedo.
• Organic Radicals and Radical Dendrimers to improve the Magnetic Resonance Imaging. CIBER-BBN. Intramural Project 2018-2019. Instituto Carlos III. 1/03/2018 – 31/3/2020. Coordinador y PI: José Vidal Gancedo.
• Radicales y dendrímeros radicales para imagen de Resonancia Magnética Nuclear y otras aplicaciones bio. Intramural CSIC. Nº: 201760E080. 1/10/2017 – 31/10/2019. PI: José Vidal Gancedo.
• Grup de Recerca Consolidat: Materials Orgànics i Nanociència Molecular, ICMAB (CSIC).  AGAUR. Nº: 2017 SGR 918. 1/01/2017 – 31/12/2019. PI: Jaume Veciana.
• MOTHER. Molecule-based materials and supramolecular organizations for therapy, diagnosis and tissue engineering. MAT2016-80826-R, Ministerio de Economia y Competitividad; 01/01/2017 - 31/12/2019; PI: Jaume Veciana and Nora Ventosa. Work Package WPA3: Radical molecules as DNP agents and WPA4: Radical dendrimers as MRI relaxing agents are lidded by José Vidal Gancedo.
• BE-WELL. Bio- and Electro-active molecule-based materials for improving health andsocietal WELLbeing. CTQ2013-40480-R, Ministerio de Economia y Competitividad; 01/01/2014 - 3106/2017; PI: Jaume Veciana and Concepció Rovira. Work Package WPA2: Novel radical molecules for using as polarizing agents for DNP and as contrast agents for MRI imaging, are lidded by José Vidal Gancedo.
• ORDECA. Organic Radicals and Radical Dendrimers as Contrast Agents for Nuclear Magnetic Resonance Imaging. Nº: NM19. Intramural Project 2016-2017. Instituto Carlos III. Ciber-BBN. 01/04/2016 - 1/04/2018. Coordinator and PI: José Vidal Gancedo.
• HEPOR. Estudio de la heparina y sus procesos de oxidación por Resonancia Paramagnética Electrónica. Bioiberica S.A. 01/03/2016 - 1/12/2016. PI: José Vidal Gancedo.

   

• Aharon Blank, Jens Anders, Vega Lloveras y José Vidal-Gancedo. Minimally-invasive continuous clinical monitoring of small molecules with analytical accurancy. Nº: US 62/17777684. Technion Research and Development Foundation LTD, University of Stuttgart, CSIC. 2023
• Aharon Blank, Jens Anders, Vega Lloveras y José Vidal-Gancedo. Minimally-invasive continuous clinical monitoring of small molecules with analytical accurancy. Nº: PCL/IL20/051197. Technion Research and Development Foundation LTD, University of Stuttgart, CSIC. 2020. Signed exploitation agreement and licensed.
• Vidal-Gancedo, V. Lloveras. Metal-free MRI T1 contrast agents based on PPH Gn-Tyr-PROXYL radical dendrimers. Third generation dendrimer, process for production thereof and use thereof. Nº: PCT/EP20/070657. CSIC. 2020.
• Vidal-Gancedo, V. Lloveras. Metal-free MRI T1 contrast agents based on PPH Gn-Tyr-PROXYL radical dendrimers. Third generation dendrimer, process for production thereof and use thereof. Nº: EP1641.1463. CSIC. 2019.
• Aharon Blank, Jens Anders, Vega Lloveras, José Vidal-Gancedo. Minimally-invasive continuous clinical monitoring of small molecules with analytical accurancy. Nº: US 62/751637. Technion Research and Development Foundation LTD, University of Stuttgart, CSIC. 2018
• Aharon Blank, Jens Anders, Vega Lloveras, José Vidal-Gancedo. Minimally-invasive continuous clinical monitoring of small molecules with analytical accurancy. Nº: US 62/577775. Technion Research and Development Foundation LTD, University of Ulm, CSIC. 2017
• Aharon Blank, Jens Anders, Vega Lloveras y José Vidal-Gancedo. Minimally-invasive continuous blood glucose monitoring system. Nº: US 62/412879. Technion Research and Development Foundation LTD, University of Ulm, CSIC. 2016
• J. Vidal-Gancedo, V. Lloveras, V. Chechik. Magnetic spin labeled gold nanoparticles. Nº: P201431230. CSIC. 2014
• J. Vidal-Gancedo, V. Lloveras, J. L. Muñoz, J. Veciana, E. Monteagudo, T. Parella. Derivados de 1,3-bisdifenilen-2-fenilalilo y su aplicación en Polarización Nuclear Dinámica. Nº: P201431388. CSIC, UAB. 2014

Radicals as polarizing agents in Dynamic Nuclear Polarization (DNP)

Dynamic nuclear polarization (DNP) has recently revealed its potential to enhance the NMR sensitivity in solids and liquids. DNP allows for the intrinsically large spin polarization of electrons to be transferred to nuclei for detection in magnetic resonance experiments with a theoretical signal enhancement of over 600 for protons and 2400 for ¹³C. When combined with polarization at very low temperatures, sensitivity enhancements of more than 4 orders of magnitude over the Boltzmann population of the nuclear spin have been described. We are working on the synthesis of new radicals and its application as polarizing agents for future DNP-MRI applications.

Macromolecular Organic Radicals as Contrast Agents for Magnetic Resonance Imaging (MRI)

Magnetic resonance imaging (MRI) is one of the best non invasive clinical imaging methods used in medicine which takes benefit of the NMR principles. MRI contrast agents (CAs) play an important role in improving the sensitivity of the tumor diagnosis. Currently, low-molecular-weight Gd(III) chelates are the mostly used paramagnetc metal ion-based CAs in the clinic. However, patients with impaired kidney function are reported to be at increased risk of developing a serious adverse reaction named nephrogenic systemic fibrosis (NSF). Stable organic free radicals provide an alternative to Gd(III).

Our work ranges from the synthesis of new macromolecular stable organic radicals contrast agents for MRI and the development of different types of biosensors based on these systems.

Gold nanoparticles covered with organic radicals

Supramolecular magnetic assemblies can be built using a range of different materials as scaffolds: functionalized polymers, dendrimers, or metallic nanoparticles.

We are working on gold nanoparticles as supports for organic radicals to study magnetic interactions as magnetic probes.