Micro- and nanoformulation of APIs using CO2 expanded solvents
Chimica Oggi - Chemistry Today - vol. 31(6) November/December 2013
Santiago Sala, Elisa Elizondo, Evelyn Moreno-Calvo, Jaume Veciana
Chimica Oggi - Chemistry Today - vol. 31(6) November/December 2013
Santiago Sala, Elisa Elizondo, Evelyn Moreno-Calvo, Jaume Veciana
Nanomedicine, as the medical application of Nanotechnology, is a promising alternative to overcome the problems of the administration of APIs and biomolecules, either already existing drugs or new entities coming out from the discovery pipeline. In this paper we endeavour to show the potentiality of DELOS Technology Platform, which uses CO2-expanded solvents, for the one-step production of active pharmaceutical ingredients (APIs) in the form of micro- or submicron crystalline powders or colloidal preparations, with tailored characteristics in terms of size, morphology,crystallinitiy and polymorphism. DELOS is an efficient easy scalable platform for the preparation of new micro and nanoformulations for improving protection of actives against early degradation, preventing their premature interaction with the biological environment, facilitate higher ayloads, prolong their circulation life-time, improve drug targeting and solubility and provide controlled release of the therapeutics into the blood stream or the target tissues or organs.
